Breast Tumor Metastasis Following Filgrastim Administration Due to the SDF-1/CXCR4 Pathway

Researchers investigated in vitro and in vivo effects of filgrastim on cell migration, invasion, and metastasis. A lentivirus vector of the anti- C-X-C chemokine receptor type 4 (CXCR4) receptor was first used for the CXCR4 knockout.