Epigenetic Regulation of Neuregulin 1 Promotes Breast Cancer Progression Associated to Hyperglycemia

Researchers showed that hyperglycemia caused active histone modifications at the Nrg1 enhancer, forming enhanceosome complexes where recombination signal binding protein for immunoglobulin kappa J region, E1A binding protein p300, and SET domain containing 1 A were recruited to upregulate Nrg1 expression.