Loss of 5-Hydroxymethylcytosine Induces Chemotherapy Resistance in Hepatocellular Carcinoma via the 5-hmC/PCAF/AKT Axis

Investigators reported that the level of 5-hydroxymethylcytosine (5-hmC) in human HCC tissues was significantly lower than that in adjacent liver tissues, and reduced 5-hmC significantly correlated with malignant phenotypes.