Dissecting and Targeting Noncanonical Functions of EZH2 in Multiple Myeloma via an EZH2 Degrader

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Scientists uncovered a new noncanonical function of enhancer of zeste homolog 2 (EZH2) in multiple myeloma (MM) tumorigenesis and provided a novel therapeutic strategy, pharmacological degradation of EZH2, for treating EZH2-dependent MM.
[Oncogene]
Abstract