Downregulation of CAMK2N1 Due to DNA Hypermethylation Mediated by DNMT1 That Promotes the Progression of Prostate Cancer

To test whether DNA methylation could result in the reduced expression of calcium/calmodulin-dependentprotein kinase II inhibitor I (CAMK2N1) in prostate cancer, the DNA methylation level of CAMK2N1 in prostate cells and clinical specimens was determined by bisulfite sequencing, pyrosequencing, and in silico analysis.