Hypoxia Promotes Conversion to a Stem Cell Phenotype in Prostate Cancer Cells by Activating HIF-1α/Notch1 Signaling Pathway

To examine whether HIF-1α in the hypoxic microenvironment mediates the transformation of prostate cancer to a stem cell phenotype, prostate cancer stem cells from PC-3 cell lines were examined for the expression of CD44, CD133, ALDH1, HIF-1α, Notch1, and HES1.