Stabilization of E-Cadherin Adhesions by COX-2/GSK3β Signaling Is a Targetable Pathway in Metastatic Breast Cancer

The authors discovered that COX-2, a target gene of C/EBPd, or its metabolite prostaglandin E2 promoted protein stability of E-cadherin, β-catenin, and p120 catenin through inhibition of GSK3β.