DIF-1 Exhibits Anticancer Activity in Breast Cancer via Inhibition of CXCLs/CXCR2 Axis-Mediated Communication between Cancer-Associated Fibroblasts and Cancer Cells

Scientists investigated the effect of differentiation-inducing factor-1 (DIF-1) on the tumor microenvironment using mouse TNBC 4T1-GFP cells, mouse macrophage RAW 264.7 cells, and mouse primary dermal fibroblasts.