MLKL Signaling Regulates Macrophage Polarization in Acute Pancreatitis through CXCL10

An experimental pancreatitis was induced in C57BL/6J, Ripk3-/- and mixed-lineage kinase domain-like protein-/- (Mlk-/-) mice by cerulein plus lipopolysaccharide in vivo, and primary pancreatic acinar cells were also isolated to uncover cellular mechanisms during cerulein stimulation in vitro.