PIN1 and CDK1 Cooperatively Govern pVHL Stability and Suppressive Functions

Researchers identified cyclin-dependent kinase 1 (CDK1) and peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) as two previously uncharacterized regulators of protein von Hippel–Lindau (pVHL) in multiple types of human cancers harboring wild-type VHL including TNBC.