NewslettersHepatic Cell NewsSIRT3-Dependent Delactylation of Cyclin E2 Prevents Hepatocellular Carcinoma GrowthBy Bob - March 10, 20230448The authors reported that SIRT3 could delactylate non-histone proteins and suppress HCC development. Using SILAC-based quantitative proteomics, they identified cyclin E2 as one of the lactylated substrates of SIRT3 in HCC cells.[EMBO Reports]AbstractGraphical Abstract