Newsletters

[Harvard Medical School] A $46 million grant from a new autism research initiative, Aligning Research to Impact Autism, is turbocharging efforts at Harvard and Yale to understand human brain development and provide insight into the roots of profound autism.

[Virginia Tech (EurekAlert)] Dr. James Weger-Lucarelli at the Virginia-Maryland College of Veterinary Medicine, received a five-year, $2.01 million award from the National Institute of General Medical Sciences to investigate how virus-infected cells live and die, and what they signal to their neighbors when they do.

[NanoViricides, Inc. (BioSpace)] NanoViricides, Inc. announced that its Phase II Clinical Trial of NV-387 Oral Gummies as a Treatment for the Current Bundibugyo Ebolavirus and other Ebola viruses in the Democratic Republic of Congo was successfully registered in the Pan African Clinical Trials Registry.

[Nature Communications] Researchers established a genetic code expansion-based platform in mESCs for site-specific proteomic mapping and functional analysis within native chromatin. Using this platform, they revealed Rps19bp1 promotes Sirt1-mediated deacetylation of histone H2B lysine 108 acetylation.

[Nature Medicine] The authors evaluate the technological and translational trajectories that have defined the iPSC era and analyzes the operational barriers to therapeutic development.

[Cell Proliferation] Investigators leveraged their isogenic haploid, diploid and triploid hESC lines to study the effect of ploidy on the response to four different anticancer drugs. They showed that triploid cells are more sensitive to chemotherapy-induced apoptosis and cell cycle arrest than diploid and haploid cells.

[Nature Immunology] Scientists identified microbial adhesion to myeloid cells as a critical initiating event that precedes pattern recognition receptor engagement. Using a skin infection model with pathogenic bacteria and fungi, they demonstrated that neutrophil recruitment occurs in two sequential phases.

[Stem Cell Reports] Given the interplay between DNAme and the other epigenetic features, researchers profiled DNA methylation following Setdb1 knockout in ground-state and serum-grown mESCs to illuminate DNAme-dependent and -independent functions of SetDB1.

[PLoS Genetics] Researchers demonstrated that post-transcriptional regulation of the Profilin 2 transcript is essential for differentiation of ESCs into the primary germ layer lineages.

[Cancer Letters] Researchers used a hPSC model of neuroblastoma to show that 17q+ cooperates with MYCN amplification to accelerate tumorigenesis compared to MYCN amplification alone.

[International Journal of Stem Cells] Scientists introduced O-cyclic phytosphingosine-1-phosphate (cP1P), a novel culture additive structurally analogous to S1P, which markedly enhances hPSC self-renewal and survival. They demonstrated that cP1P supplementation promotes long-term proliferation of hPSCs.

[Immunity] Researchers studied individuals sequentially infected with SARS-CoV-1 and SARS-CoV-2 over two decades and found durable imprinting of antibody responses following SARS-2 BF.7 breakthrough infection.