Secreted Protease PRSS35 Suppresses Hepatocellular Carcinoma by Disabling CXCL2-Mediated Neutrophil Extracellular Traps

Researchers showed that the secreted pseudo serine protease PRSS35 functions as a tumor suppressor in HCC. Mechanistically, they demonstrated that active PRSS35 was processed via cleavage by proprotein convertases.