Newsletters

[TCM Biotech] TCM Biotech has received FDA Breakthrough Device Designation for CatCHimera, a liquid biopsy MRD platform for HCC that uses HBV–host genome integration junctions — rather than somatic mutations — as tumor-specific circulating biomarkers for post-curative treatment monitoring.

[Advanced Science] Researchers identified an N-methyltransferase (NNMT)-ANGPTL4-driven metabolic-epigenetic cascade in cancer-associated fibroblasts that induces PD-L1-mediated immune evasion, providing a therapeutic strategy to overcome resistance to immunotherapy in patients with HCC.

[Advanced Healthcare Materials] Scientists elucidated a polymeric nanomedicine integrated with protein-binding fluorophore and bevacizumab, named PNPB, that was activated by fibroblast activation protein (FAP), a biomarker of liver fibrosis.

[Journal of Nanobiotechnology] Investigators identified fibrinogen gamma chain (FGG) as a key fibrosis promoter that acts through simultaneous hepatic stellate cell activation and M2 macrophage polarization.

[Journal of Medicinal Chemistry] To enhance cyclic peptide GG-8–6: cyclo-(VLLLIPLVL)'s tumor targeting and bioavailability in HCC, the authors designed and synthesized a fluorescent RGD-modified cyclic peptide, CP38, which selectively recognized the αvβ3 integrin.

[Journal of Gastroenterology] Researchers identified FIRRM (fidgetin-like 1-interacting regulator of recombination and mitosis) as a novel driver gene in HCC, which accelerated tumor proliferation through PLK1-mediated mitotic progression and promotion of the G2/M transition.

[Scientific Reports] Scientists investigated the therapeutic potential of Astaxanthin and its impact on Wnt/β-catenin pathway in a rat model, inducing HCC by nitrosodiethylamine and carbon tetrachloride.

[Scientific Reports] The functional role of ADAM15 in HCC was investigated both in vitro and in vivo. ADAM15 knockdown inhibited the proliferation, migration, and invasion of HCC cells, whereas ADAM15 overexpression enhanced these malignant behaviors.

[Hepatology Research] Researchers used bioinformatics approaches such as metabolic scoring, drug sensitivity analysis, and metabolic profiling, combined with in vitro and in vivo functional assays to elucidate the novel mechanisms underlying the therapeutic effects of lenvatinib.

[Journal of Nanobiotechnology] The authors provide a comprehensive synthesis of the current landscape in blood extracellular vesicle proteomics for HCC.

[Nature Communications] Researchers demonstrated that a ketogenic diet maintained homeostasis under physiological conditions but exacerbated colitis by triggering a ketogenesis-microbe-immune cascade upon mucosal injury.

[JCI Insight] Scientists developed a stromal coculture system using MS5 cells engineered to express human CD40L, BAFF, and IFN-β1. This culture platform robustly induced the expansion of human IL-10–producing B cells, while predominantly generating unswitched plasmablasts.