Live-Attenuated Vaccine sCPD9 Elicits Superior Mucosal and Systemic Immunity to SARS-CoV-2 Variants in Hamsters

Researchers compared immune responses and preclinical efficacy of the mRNA vaccine BNT162b2, the adenovirus-vectored spike vaccine Ad2-spike, and the live-attenuated virus vaccine candidate sCPD9 in Syrian hamsters, using both homogeneous and heterologous vaccination regimens.