Newsletters

[Cellenkos, Inc. (PR Newswire)] Cellenkos, Inc. announced that the US FDA has granted Fast Track designation to CK0803 for the treatment of Amyotrophic Lateral Sclerosis (ALS). CK0803 is an investigational, allogeneic, cord blood-derived Treg cell therapy engineered to express high levels of CXCR3 and CD11a.

[Immunity] Researchers compared ovalbumin (OVA)-specific T cell fates using mice fed OVA, or expressing secreted, cytosolic (c), or transmembrane epithelial OVA. BATF3+ antigen-presenting cells were indispensable for CD4+ T cell proliferation only in cOVA mice, yet they drove Treg cell differentiation across all epithelial OVA models.

[EMBO Journal] Investigators showed that agonistic anti-CD137 monoclonal antibodies target multiple CD137-expressing cell types, including activated CD8⁺ T-cells, Tregs, follicular Tregs, and follicular dendritic cells.

[Nature Communications] Scientists investigated the function of CD97/ADGRE5, expressed in mouse and human immune and lung epithelial cells, in allergic asthma. A single CD97 antibody treatment before allergen sensitization worsens allergic responses, highlighting a role for CD97 in early immune regulation.

[Science Advances] Scientists demonstrated that HMGCS1, a cholesterol biosynthesis precursor enzyme, was highly induced by inflammatory cytokines and preferentially expressed by pathogenic T helper 17 cells in vitro and in vivo.

[Blood] Researchers showed that CD4+ naive T cells from patients with immune thrombocytopenia exhibit diminished T cell receptor signaling and impaired in vitro Treg induction relative to healthy controls.

[Cellular & Molecular Immunology] The authors highlight immunometabolism as a key mechanism in autoimmunity. Immunometabolic pathways represent a new avenue for precision immunotherapy, although challenges persist in targeting cells specifically without systemic toxicity.

[Science Advances] Scientists showed that the histone variant H3.3 is enriched in tissue Tregs compared to splenic Tregs and its chaperone Hira is a critical regulator of Treg effector program.

[Nature Reviews Immunology] Investigators describe the molecular mechanisms by which multiple epigenetic layers, encompassing DNA methylation, histone modification, chromatin remodelling, non-coding RNA regulation and RNA modification, collectively regulate normal B cell function and, when dysregulated, contribute to autoimmune pathogenesis.

[Gastroenterology] To understand how hepatocytes cope with mitotic challenges, the authors established a high-quality in vivo CRISPRi screen in regenerating mouse liver. By cross-referencing with gene essentiality data in cell lines, they identified genes required specifically by hepatocytes for proliferation.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists developed an activated hepatic stellate cells (aHSCs)-targeted nanoplex that activates the stimulator of interferon genes pathway to induce senescence in aHSCs, while promoting endogenous immune surveillance-mediated clearance of aHSCs.

[Cell Reports] Researchers developed a patient-derived liver cancer organoid platform for high-throughput drug screening, identifying promising drug candidates and combination therapies across heterogeneous tumors.