CircPVT1 Promotes ER-Positive Breast Tumorigenesis and Drug Resistance by Targeting ESR1 and MAVS

Investigators reported that circPVT1, a circular RNA generated from the lncRNA PVT1, was highly expressed in estrogen receptor (ER)α-positive breast cancer cell lines and tumor samples and was functionally important in promoting ERα-positive breast tumorigenesis and endocrine therapy resistance.