Antitumor Effect of a Novel Humanized MUC1 Antibody-Drug Conjugate on Triple-Negative Breast Cancer

Researchers developed a novel humanized antibody that specifically bound MUC1 expressed in breast cancer cells and conjugated a humanized MUC1 (HzMUC1) antibody to monomethyl auristatin (MMAE). HzMUC1-MMAE showed an anti-proliferative effect on HER2 positive trastuzumab-resistant breast cancer.