Therapeutic Effects of Anti-GM2 CAR-T Cells Expressing IL-7 and CCL19 for GM2-Positive Solid Cancer in Xenograft Model

Using interleukin (IL)-7 and chemokine ligand 19 (CCL19)-producing human CAR-T system, researchers explored the possibility of GM2 as a solid tumor target for CAR-T cell therapy in a mouse model with human small-cell lung cancer.