Drug Transporter Expression and Activity in Cryopreserved Human Hepatocytes Isolated from Chimeric TK-NOG Mice with Humanized Livers

Because drug transporters are now recognized as key-actors of the hepatic detoxifying process, the present study was designed to characterize mRNA expression and activity of main hepatic drug transporters in cryopreserved human hepatocytes isolated from chimeric TK-NOG mice and termed HepaSH cells.