N-acetylcysteine Overcomes NF1 Loss-Driven Resistance to PI3Kα Inhibition in Breast Cancer

Depletion of NF1 in PIK3CAH1047R breast cancer cell lines and a patient-derived organoid model showed that NF1 loss reduced sensitivity to phosphatidylinositol 3-kinase α (PI3Kα) inhibition and correlated with enhanced glycolysis and lower levels of reactive oxygen species.