Insulin Secretion Deficits in a Prader-Willi Syndrome β Cell Model Are Associated with a Concerted Downregulation of Multiple Endoplasmic Reticulum Chaperones

To determine the collective roles of Prader-Willi syndrome genes in β-cell biology, researchers used genome-editing to generate isogenic, clonal INS-1 insulinoma lines having 3.16 Mb deletions of the silent, maternal- and active, paternal-allele.