IL-6–GP130 Signaling Protects Human Hepatocytes against Lipid Droplet Accumulation in Humanized Liver Models

Investigators demonstrated that abnormal lipid accumulation in transplanted human hepatocytes was associated with compromised interleukin-6 (IL-6)–glycoprotein 130 (GP130) signaling in human hepatocytes because of incompatibility between host rodent IL-6 and human IL-6 receptor on donor hepatocytes.