A Robust Reprogramming Strategy for Generating Hepatocyte-Like Cells Usable in Pharmaco-Toxicological Studies

Scientists designed and implemented a novel and robust approach to obtain hepatocytes from individuals by direct reprogramming. This strategy allows the generation of an unlimited source of clonal, homogeneous, non-transformed induced hepatocyte-like cells, capable of performing typical hepatic functions and suitable for pharmaco-toxicological high-throughput testing.