Downregulation of the RNA-Binding Protein PUM2 Facilitates MSC-Driven Bone Regeneration and Prevents OVX-Induced Bone Loss

Scientists suggested a novel role for PUMILIO2 (PUM2) in MSC osteogenesis and highlighted the potential of PUM2 knockdown-MSCs in bone regeneration. Additionally, they showed that AAV9-siPum2 is a potential gene therapy for osteoporosis.