Intrinsic Tumor Resistance to CAR T Cells Is a Dynamic Transcriptional State That Is Exploitable With Low-Dose Radiation

Researchers found that substantially reducing systemic tumor quantity using high-dose radiation to bulky disease, which is commonly done clinically, was less impactful on overall survival in mice achieved by CAR T-cells than targeting all sites of disease with low-dose total tumor radiation prior to CAR T-cells.