Isocitrate Dehydrogenase 1 Sustains a Hybrid Cytoplasmic–Mitochondrial Tricarboxylic Acid Cycle That Can Be Targeted for Therapeutic Purposes in Prostate Cancer

Mouse models, in vitro human prostate cancer (PCa) cell lines, and human patient-derived organoids were used to study the expression and activity of isocitrate dehydrogenase enzymes in the normal prostate and PCa.