The In Vitro Pro-Inflammatory Functions of the SP/NK1R System in Prostate Cancer: A Focus on Nuclear Factor-Kappa B (NF-κB) and Its Pro-Inflammatory Target Genes

Scientists investigated the pro-inflammatory functions of the substance P (SP)/neurokinin receptor (NK‐1R) complex in prostate cancer and the therapeutic effects of its inhibition by NK‐1R antagonist, aprepitant, in vitro.