Novel Fas-TNFR Chimeras That Prevent Fas Ligand-Mediated Kill and Signal Synergistically to Enhance CAR T Cell Efficacy

Co-expression of Fas-CD40 with either 4-1BB- or CD28-containing CARs increased in vitro efficacy by augmenting CAR T cell proliferation and cancer target cytotoxicity, and enhanced tumor killing and overall mouse survival in vivo.