Hepatic Stellate Cell Stearoyl Co-A Desaturase Activates Leukotriene B4 Receptor 2 – β-Catenin Cascade To Promote Liver Tumorigenesis

Scientists reported that selective ablation of stearoyl CoA desaturase-2 in activated hepatic stellate cells globally suppressed nuclear CTNNB1 and YAP1 in tumors and tumor microenvironment and prevents liver tumorigenesis in male mice.