Hypoxia-Induced Loss of SRSF2-Dependent DNA Methylation Promotes CTCF-Mediated Alternative Splicing of VEGFA in Breast Cancer

Investigators demonstrated that the splicing factor SRSF2 caused the inclusion of exon-8b, leading to the formation of the anti-angiogenic vascular endothelial growth factor A (VEGFA)-165b isoform under normoxic conditions.