Newsletters

[Nature Communications] Scientists investigated how Myosin Light Chain Phosphorylatable Fast (Mylpf) abundance impacts sarcomere growth. The two zebrafish Mylpf genes, mylpfa and mylpfb, are exclusively expressed in fast-twitch muscle, with mylpfa expressed more abundantly than mylpfb.

[Nature Biomedical Engineering] Researchers reported the systemic delivery of skeletal-muscle-targeted full-length DMD mRNA in a murine model of Duchenne muscular dystrophy (DMD) using allogenically engineered targeting extracellular vesicles.

[Cell Stem Cell] The authors created pleiotropic chimeric antigen receptor (CAR)-monocytes, revitalizing the injured heart via synergistic fibrosis clearance and myocardial reconstitution.

[Proceedings of the National Academy of Sciences of the United States of America] Using a mouse that lacks a large intracellular region of β-dystroglycan (DG), researchers showed that the deletion of cytoplasmic β-DG leads to skeletal muscle pathology accompanied by postsynaptic disruption.

[Proceedings of the National Academy of Sciences of the United States of America] Using single-sarcomere imaging of skeletal muscle myofibrils under near-physiological conditions, investigators directly visualized myosin motors OFF-to-ON switch transitions within distinct regulatory zones of the filaments.

[Cell Death & Disease] Scientists reported upregulation of histone methyltransferase G9a in both aged human muscle and mouse muscle after injury. Deletion of G9a in either myeloid cells or myofibers accelerates muscle regeneration.

[Advanced Science] Through spatial proteomics of human colon and functional assays in primary human colonic smooth muscle cells, investigators identified Bridging Integrator 1 (BIN1) and Aldehyde Dehydrogenase 1B1 (ALDH1B1) as key regulators of intestinal motility.

[Skeletal Muscle] Scientists examine how enhancer-associated mechanisms enable muscle stem cells to interpret niche-derived signals, highlighting the roles of transcription factor networks, chromatin remodeling complexes, and enhancer-promoter interactions in coordinating gene expression.

[GEn1E Lifesciences, Inc. (Business Wire)] GEn1E Lifesciences, Inc. announced that the US FDA has granted both Orphan Drug Designation and Rare Pediatric Disease Designation to GEn-1123 for the treatment of Duchenne Muscular Dystrophy.

[RadioMedix, Inc.] RadioMedix, Inc. announced that the US FDA has approved Ga 68 PSMA-11, a prostate-specific membrane antigen (PSMA)-targeted diagnostic radiopharmaceutical for positron emission tomography imaging in patients with prostate cancer.

[University of Houston] With $250,000 in Cancer Prevention and Research Institute of Texas (CPRIT) funding, Dr. Qin Feng, associate professor of biology and biochemistry, is working to stop the progression of prostate cancer. Her research goal is to provide a new treatment option for prostate cancer patients, especially those resistant to current therapies.

[Oncogene] Liquid chromatography-mass spectrometry identified LTBP1 as a direct interacting partner of methylcrotonyl-CoA carboxylase subunit 2 (MCCC2). Functional studies demonstrated that MCCC2 promotes prostate cancer cell migration, invasion in vitro, and bone metastasis in vivo.