Newsletters

[Nature] Investigators showed that restoring plasticity in parvalbumin neurons can improve cognition and suppress seizures in a neurodevelopmental disorder model, suggesting that some developmental circuit deficits may be reversible in adulthood.

[Nature Genetics] Scientists developed a high-content screening to investigate how Alzheimer’s disease genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures.

[Nature Neuroscience] Researchers developed STARFISH, a method for visualizing the subcellular site of endogenous mRNA translation in primary neurons and in vivo with single-molecule sensitivity and near-codon resolution, without modifying the nascent polypeptide.

[Cell Reports] Scientists identified pleiotrophin (Ptn) as a regulator of presynaptic development. Affinity purification-based proteomics shows that Ptn associates with heparan sulfate (HS)-modified neurexin1 in the brain through an HS-glycan-dependent mechanism.

[Communications Biology] The authors investigated whether daily light exposure promotes photoreceptor maturation by exposing retinal organoids to six hours of daily light starting from day 70 in vitro.

[Cancer Gene Therapy] Researchers investigated the use of stem cells from human exfoliated deciduous teeth (SHED) as a potential vehicle for oncolytic herpes simplex virus-1 therapy to enhance treatment efficacy.

[Trends in Pharmacological Sciences] The authors review emerging strategies to selectively target pathological tau, from gene silencing and immunotherapy to protein degradation and tau modification, for treating neurodegenerative diseases.

[Molecular Psychiatry] Scientists summarize current findings on GABA-mediated glial-neuronal crosstalk, with emphasis on its roles in CNS physiology and its multifaceted regulation in neurological and neuropsychiatric disorders.

[Experimental & Molecular Medicine] Investigators highlight how neural signals shape the tumor immune microenvironment, revealing neuroimmune pathways as potential targets to overcome immune evasion and enhance cancer immunotherapy.

[Enigma Biomedical USA (Business Wire)] Enigma Biomedical USA announced the US FDA approval of TAUKLARIFY™, a radiodiagnostic agent indicated for positron emission tomography of the brain in adults with cognitive impairment who are being evaluated for Alzheimer’s disease to identify patients with tau neurofibrillary tangle pathology.

[Nature Biotechnology] Investigators presented a virus-like particle-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness.

[Nature Cell Biology] Using single-cell RNA-sequencing of the bone-marrow microenvironment in a mouse model of DNMT3A-mutant clonal haematopoiesis, scientists identified mesenchymal stromal cells in a molecular state of cellular senescence.