NewslettersHepatic Cell NewsPolyphyllin D “Punctures” Hypertrophic Lysosomes to Reverse Drug Resistance of Hepatocellular Carcinoma by Targeting Acid SphingomyelinaseBy Laurisa Dohm - May 26, 20230269Polyphyllin D-enhanced lysosomal membrane permeabilization to release sorafenib, augmenting the anticancer effect of sorafenib both in vivo and in vitro.[Molecular Therapy]AbstractGraphical Abstract