FOXK1 Promotes Nonalcoholic Fatty Liver Disease by Mediating mTORC1-Dependent Inhibition of Hepatic Fatty Acid Oxidation

Hepatocyte-specific deletion of Foxk1 in mice fed a NASH-inducing diet ameliorated not only hepatic steatosis, but also associated inflammation, fibrosis, and tumorigenesis, resulting in improved survival.