Single-Cell Transcriptomics Identifies Perturbed Molecular Pathways in Midbrain Organoids Using α-Synuclein Triplication Parkinson’s Disease Patient-Derived iPSCs

Investigators generate midbrain dopaminergic organoids from induced pluripotent stem cells from healthy and Parkinson’s Disease (PD) donors and assess them as a human PD model using single-cell RNAseq.