17β-Estradiol Promotes Extracellular Vesicle Release and Selective miRNA Loading in ERα-Positive Breast Cancer

Scientists reported that physiological doses of 17β-estradiol promoted extracellular vesicle (EV) secretion specifically from estrogen receptor–positive breast cancer cells via inhibition of miR-149-5p, hindering its regulatory activity on SP1, a transcription factor that regulated the EV biogenesis factor nSMase2.