O-GlcNAcylation Promotes Topoisomerase IIα Catalytic Activity in Breast Cancer Chemoresistance

The authors investigated the role of topoisomerase IIα (TOP2A) O-GlcNAcylation in breast cancer cells and patient tumor tissues. They demonstrated that elevated TOP2A, especially its O-GlcNAcylation, promoted breast cancer malignant progression and resistance to adriamycin.