Targeting CXCR4 Abrogates Resistance to Trastuzumab by Blocking Cell Cycle Progression and Synergizes with Docetaxel in Breast Cancer Treatment

Immunofluorescent staining, confocal microscopy analysis, and immunoblotting were used to analyze C-X-C motif chemokine receptor 4 (CXCR4) expression. BrdU incorporation assays and flow cytometry were used to analyze dynamic CXCR4 expression.