Exosomal miR-6733-5p Mediates Cross-Talk Between Glioblastoma Stem Cells and Macrophages and Promotes Glioblastoma Multiform Progression Synergistically

Glioblastoma stem cells (GSCs)-derived exosomal miR-6733-5p induced macrophage M2 polarization of tumor-associated macrophages by positively targeting IGF2BP3 to activate the AKT signaling pathway, which further facilitated the self-renewal and stemness of GSCs.