MeCP2 Dysfunction Prevents Proper BMP Signaling and Neural Progenitor Expansion in Brain Organoid

Investigators established the Rett syndrome (RTT) brain organoid model derived from MeCP2-truncated induced pluripotent stem cells which were genetically engineered by CRISPR/Cas9 technology. By immunofluorescence imaging, they studied the development of neural progenitor cell pool and its fate specification into glutamatergic neurons or astrocytes in RTT organoids.