Breast Cancer Cell Mesenchymal Transition and Metastasis Directed by DAP5/eIF3d-Mediated Selective mRNA Translation

Using genome-wide transcriptomic and translatomic studies, an alternate mechanism of cap-dependent mRNA translation by the DAP5/eIF3d complex was shown to be essential for metastasis, epithelial-to-mesenchymal transition, and tumor directed angiogenesis.