Fate and Efficacy of Engineered Allogeneic Stem Cells Targeting Cell Death and Proliferation Pathways in Primary and Brain Metastatic Lung Cancer

Researchers created and characterized diagnostic and therapeutic stem cells, expressing epidermal growth factor receptor (EGFR)-targeted nanobody fused to the extracellular domain of death DR4/5 ligand that simultaneously targeted EGFR and DR4/5, in non-small cell lung cancer tumor models.