PTBP1 Promotes Hepatocellular Carcinoma Progression by Regulating the Skipping of Exon 9 in NUMB Pre-mRNA

Researchers observed significant up-regulation of polypyrimidine tract binding protein 1 (PTBP1) in primary HCC tissues. High levels of PTBP1 expression were associated with poor prognosis and increased metastatic potential in HCC.