Chimeric Antigen Receptor T Cells Targeting FcRH5 Provide Robust Tumour-Specific Responses in Murine Xenograft Models of Multiple Myeloma

Researchers showed that FcRH5 was expressed on multiple myeloma cells and could be targeted with CAR-T cells. FcRH5 CAR-T cells elicited antigen-specific activation, cytokine secretion, and cytotoxicity against multiple myeloma cells.