Small Extracellular Vesicle-Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma

Proteomic profiling of circulating small extracellular vesicles of control individuals and HCC patients identified von Willibrand factor (vWF) to be upregulated progressively along HCC stages.