Chromatin Accessibility Uncovers KRAS-Driven FOSL2 Promoting Pancreatic Ductal Adenocarcinoma Progression through Up-Regulation of CCL28

To characterize the epigenetic landscape of genetically engineered mouse models of PDAC, with or without KRAS and/or TP53 mutations, scientists employed ATAC-seq, H3K27ac ChIP-seq, and RNA-seq.