A Novel TREM1/DAP12-Based Multiple Chain CAR-T Cell Targets PTK7 in Ovarian Cancer Therapy

Scientists developed and evaluated the efficacy of novel CAR-T cells targeting PTK7 through TREM1/DAP12 signaling against ovarian cancer. The expression of PTK7 in ovarian cancer tissues and cells was evaluated using immunohistochemical staining and flow cytometric analysis.