Inserting EF1α-Driven CD7-Specific CAR at CD7 Locus Reduces Fratricide and Enhances Tumor Rejection

Researchers developed a 2-in-1 strategy to insert EF1α-driven CD7-specific CAR at the disrupted CD7 locus and compared it to two other known strategies: one was random integration of CAR by a retrovirus and the other was site-specific integration at T cell receptor alpha constant locus, both in the context of CD7 disruption.