Ablation of KIF2C in Purkinje Cells Impairs Metabotropic Glutamate Receptor Trafficking and Motor Coordination in Male Mice

Researchers showed that kinesin family member 2C (KIF2C) regulated the transport of mGlu1 receptors in Purkinje cells by binding to Rab8. KIF2C deficiency in Purkinje cells results in abnormal gait, reduced balance ability, and motor incoordination in male mice.